COMMERCIAL BIOCONTROL PRODUCTS AVAILABLE IN THE U.S.A.
FOR USE AGAINST PLANT PATHOGENS

The following is a list of commercially available products whose availability to growers in the U.S.A. has been independently verified. Most of these products have been formulated for the biocontrol of plant pathogens.  Several are listed as plant growth promoters or used for plant protection from frost damage, and they are listed because of their potential  benefit to plant health. The list was last updated on June 15, 2005.

There is a separate list of bioherbicides being developed as well.

Mention of a trademark or proprietary product does not constitute a guarantee or warranty of the product by the USDA, The Ohio State University, the American Phytopathological Society or any of its members, and does not imply approval to the exclusion of other products that may also be suitable. This list is provided for information purposes only. Contact Dr. Brian McSpadden Gardener for questions or comments.

Other web sites that list information on commercially available biological control products and other biopesticides can be found at :
http://www.epa.gov/pesticides/biopesticides/

http://www.ippc.orst.edu/biocontrol/biopesticides/
http://pestdata.ncsu.edu/ir-4/apps/news/BioCompanies.htm

 

Products listed by product name

 

Actigard   Actinovate   AF36  afla-guard  AQ10  Aspire  AtEze

Ballad  Bio-save   BioYield   BlightBan

Cedomon   Companion   Contans WG, Intercept WG

Deny  DiTera   EcoGuard   Frostban 

Galltrol   Green Releaf

HiStick N/T   Intercept    Kodiak  MeloCon WG   Mepplus

Messenger     Mycostop   Nogall      

Plant Shield  Primastop  RootShield   

Serenade Sonata  SoilGard    Spot-Less Subtilex

Taegro  T22  Yieldshield


 

Products listed by biocontrol organism

Bacteria

  Fungi
Plant growth promoters* or frost protection

*May or may not have antagonist activities against plant pathogens.

** As of September 2004 the EPA has zero tolerance for biopesticides containing Burkholderia cepacia.

 

Products listed alphabetically:

Actigard  

Biocontrol Agent: acibenzolar-S-methyl.

Target Pathogen/Disease: Many. 

Crop: Tobacco, tomato, lettuce, spinach.

Formulation: water dispersible granule.

Application Method: drench 

Manufacturer/Distributor: Syngenta Crop Protection  P.O. Box 18300, Greensboro, NC 27419 USA. Phone:  1-800-334-9481 www.syngentacropprotection-us.com/

 

Actinovate*

Biocontrol Organism: Streptomyces lydicus                                                    

Target Pathogen/Disease: soilborne disease

Crop: greenhouse and nursery crops, turf

Formulation: water-dispersible granule

Application Method: drench

Manufacturer/Distributor: Natural Industries, Inc. 6223 Theall Rd., Houston, TX 77066 USA. Phone: 888-261-4731, FAX: 281-580-4163.  http://www.naturalindustries.com/index.html

 

AF36
Biocontrol Organism: Aspergillus flavus AF36
Target Pathogen/Disease: Aspergillus flavus strains that pruduce aflatoxin
Crop: cotton
Formulation: sterilized wheat seeds colonized by A. flavus
Application Method: aerial or ground equipment
Manufacturer/Distributor: Arizona Cotton Research and Protection Council, 3721 East Wier Ave., Phoenix, AZ 85040 USA.

afla-guard

Biocontrol Organism: Aspergillus flavus NRRL 21882
Target Pathogen/Disease: Strains of the fungus A. flavus that produces aflatoxin
Crop: Peanut
Formulation: granules containing 0.01% A. flavus NRRL 21882
Application Method: applied to soil at 1 gram ai/acre once per year, 40-80 days after the peanuts are planted
Manufacturer/Distributor: Circle One Global, Inc. One Arthur Street, PO Box 28, Shellman, GA 39886-0028. Phone: 229-768-2538

AtEze

Biocontrol Organism: Pseudomonas chlororaphis 63-28
Target Pathogen/Disease: wilt diseases as well as stem and root rots
Crop: ornamentals and vegetables grown in greenhouses
Formulation:
Application Method: drenching
Manufacturer/Distributor: Turf Science Laboratories, Inc., 2121 Hoover Ave., National City, CA 91950 USA.
 

AQ10 Biofungicide**

Biocontrol Organism: Ampelomyces quisqualis isolate M-10
Target Pathogen/Disease: powdery mildew
Crop: apples, cucurbits, grapes, ornamentals, strawberries, and tomatoes
Formulation: water-dispersible granule
Application Method: spray
Manufacturer/Distributor: Ecogen, Inc., 2005 Cabot Blvd. West, Langhorne, PA 19074; Phone: 1-215-757-1590; FAX: 1-215-752-2461

 

Ballad
Biocontrol Agent: Bacillus pumilus QST2808
Target Crop/Pathogen: Asian soybean rust
Crop: soybeans
Formulation: liquid
Application: spray
Manufacturer/Distributor: AgraQuest, Inc., 1530 Drew Avenue, Davis, CA 95616 USA. Phone: 1-530-750-0150, Fax: 1-530-750-0153, www.agraquest.com
 

BINAB T Wettable Powder Biorational Fungicide

Biocontrol Agent: Trichoderma harzianum ATCC 20476 and Trichoderma polysporum ATCC 20475
Target Pathogen/Disease: fungi that infect tree wounds
Crop: ornamental, shade, and forest trees
Formulation: powder   
Application: as a slurry to the wound
Manufacturer/Distributor: BINAB Bio-Innovation EFTR AB, Florettgatan 5, SE-254 67 Helsingborg, Sweden. Phone: 46-42-16-37-04, Fax: 46-42-16-24-97, www.algonet.se/~binab/index2.html

Bio-save 10LP, 110

Biocontrol Organism: Pseudomonas syringae
Target Pathogen/Disease: Botrytis cinerea, Penicillium spp., Mucor pyroformis, Geotrichum candidum
Crop: pome fruit, citrus, cherries, and potatoes
Formulation: lyophilized product, frozen cell concentrated pellets
Application Method: pellets added to water to produce liquid suspension, postharvest application to fruit as drench, dip or spray
Manufacturer/Distributor: JET Harvest Solutions, PO Box 915139, Longwood, FL 32791 USA. Phone: 1-877-866-5773, www.jetharvest.com
 

BlightBan A506**

Biocontrol Organism: Pseudomonas fluorescens A506
Target Pathogen/Disease: Frost damage, Erwinia amylovora, and russet-inducing bacteria
Crop: almond, apple, apricot, blueberry, cherry, peach, pear, potato, strawberry, tomato
Formulation: wettable powder
Application Method: bloom time spray of the flower and fruit
Manufacturer/Distributor: NuFarm Inc., 1-708-754-3330, www.nufarm.com
 
Companion
Biocontrol Organism: Bacillus subtilisGB03, other B. subtilis,B. lichenformis, B. megaterium
Target Pathogen/Disease: Rhizoctonia, Pythium, Fusarium,and Phytophthora
Crop: Greenhouse and nursery
Formulation: liquid
Application Method: drench at time of seeding and transplanting or as a spray for turf
Manufacturer/Distributor: Growth Products, Ltd., PO Box 1252, Westmoreland Ave., White Plains, NY 10602 USA. Phone: 1-800-648-7626, Fax: 914-428-2780, Internet: www.growthproducts.com
 

Contans WG, Intercept WG

Biocontrol Organism: Coniothyrium minitans
Target Pathogen/Disease: Sclerotinia sclerotiorum and S. minor
Crop: many
Formulation: water dispersible granule
Application Method: spray
Manufacturer/Distributor: Prophyta Biologischer Pflanzenschutz GmbH, Inselstrasse 12, D-23999 Malchow/Poel, Germany; Phone: 49-38425-230, Fax: 49-38425-2323, Internet: www.prophyta.com  US Distributor: Sylvan Bioproducts, Inc., 333 Main Street, PO Box 249, Saxonburg, PA 16056-0249 USA. Phone: 1-724-352-7520, www.sylvanbio.com

 

 

Deny

Biocontrol Organism: Burkholderia cepaciatype Wisconsin

Target Pathogen/Disease: Rhizoctonia, Pythium, Fusarium, and disease caused by lesion, spiral, lance, and sting nematodes

Crop: alfalfa, barley, beans, clover, cotton, peas, grain sorghum, vegetable crops, and wheat
Formulation: peat-based dried biomass from solid fermentation; aqueous suspension
Application Method: applied to seeds with a sticking agent in planter box (aqueous suspension formulation is for use in drip irrigation or as a seedling drench)
Manufacturer/Distributor: Helena Chemical Company, 225 Schilling Blvd., Collierville, TN 38017 USA. www.helenachemical.com

 

DiTera  

Biocontrol Organism: fermentation product of killed Myrothecium verrucaria (killed) 

Target Pathogen/Disease: Parasitic nematodes 

Crop: cole crops, grape, ornamentals, turf, trees. 

Formulation: powder and liquid suspension from fermentation. 

Application Method: applied to soil and incorporated by various methods. Manufacturer/Distributor: Valent Biosciences, Inc., 1333 N. California Boulevard #600, Walnut Creek, CA 94596, USA. Phone: 800-6-VALENT. www.valent.com

 

 

EcoGuard  

Biocontrol Organism: Bacillus licheniformis SB3086

Target Pathogen/Disease: Dollar spot, low and moderate disease pressure 

Crop: turf

Formulation: liquid spore concentrate

Application Method: standard spray equipment

 Manufacturer/Distributor: Novozymes A/S, Krogshoejvej 36, 2880 Bagsvaerd, Denmark. Phone: 45-88-24-99-99, Fax: 45-88-24-99-98; or Novozymes Biologicals, Inc., 5400 Corporate Circle, Salem, VA, 24153.

 www.novozymes.com/ecoguard

 

Frostban A
Biocontrol Organism: Pseudomonas fluorescens strains A506 and 1629RS, Pseudomonas syringae 742RS
Target Pathogen/Disease: frost-forming bacteria
Crop: certain fruits, almond, potato, and tomato crops
Formulation:
Application Method: two to four spray applications early in growing season
Manufacturer/Distributor: Frost Technology Corporation, 1333 Burr Ridge Parkway, Suite 125A, Burr Ridge, IL 60527 USA.
 

Frostban B

Biocontrol Organism: Pseudomonas fluorescens A506
Target Pathogen/Disease: frost-forming bacteria
Crop: certain fruits, almond, potato, and tomato crops
Formulation:
Application Method: two to four spray applications early in growing season
Manufacturer/Distributor: Frost Technology Corporation, 1333 Burr Ridge Parkway, Suite 125A, Burr Ridge, IL 60527 USA.

 

Frostban C
Biocontrol Organism: Pseudomonas syringae 742RS
Target Pathogen/Disease: frost-forming bacteria
Crop: certain fruits, almond, potato, and tomato crops
Formulation:
Application Method: two to four spray applications early in growing season
Manufacturer/Distributor: Frost Technology Corporation, 1333 Burr Ridge Parkway, Suite 125A, Burr Ridge, IL 60527 USA.

 

Frostban D
Biocontrol Organism: Pseudomonas fluorescens 1629RS
Target Pathogen/Disease: frost-forming bacteria
Crop: certain fruits, almond, potato, and tomato crops
Formulation:
Application Method: two to four spray applications early in growing season
Manufacturer/Distributor: Frost Technology Corporation, 1333 Burr Ridge Parkway, Suite 125A, Burr Ridge, IL 60527 USA.

Galltrol

Biocontrol Organism: Agrobacterium radiobacter Strain 84
Target Pathogen/Disease: crown gall disease caused by Agrobacterium tumefaciens
Crop: fruit, nut, and ornamental nursery stock
Formulation: petri plates with pure culture grown on agar
Application Method: bacterial mass from one plate transferred to one gallon of non-chlorinated water; suspension applied to seeds, seedlings, cuttings, roots, stems, and as soil drench
Manufacturer/Distributor: AgBioChem, Inc., 3 Fleetwood Ct., Orinda, CA 94563, USA. Phone: 1-925-254-0789 or 10795 Byrne Avenue, Red Bluff, CA, 90860 USA. Phone: 1-530-527-8028, www.crowngall.com
 

GB34 Biological Fungicide

Biocontrol Organism: Bacillus pumilus GB34
Target Pathogen/Disease: fungal pests Rhizoctonia and Fusarium
Crop: soybean seeds
Formulation:
Application Method: water slurry applied to seeds using specified mechanical seed-treating equipment
Manufacturer/Distributor: Gustafson LLC, 1400 Preston Road, Suite 400, Plano, TX 75093, USA. Phone: 972-985-5617, Fax: 972-985-1696, www.gustafson.com

 

Green Releaf
Biocontrol Organism: Bacillus licheniformis SB3086
Target Pathogen/Disease: many fungal species especially those causing leafspot and blight diseases
Crop: ornamental turf, lawns, golf courses, ornamental plants, conifers and tree seedlings in outdoor, greenhouse, and nursery sites
Formulation:
Application Method: diluted in water and sprayed on leaves or applied to soil
Manufacturer/Distributor: Novozymes A/S, Krogshoejvej 36, 2880 Bagsvaerd, Denmark. Phone: 45-88-24-99-99, Fax: 45-88-24-99-98; or Novozymes Biologicals, Inc., 111Kesler Mill Rd., Salem, VA 24153, USA; www.novozymes.com
 

HiStick N/T

Biocontrol Organism: Bacillus subtilis MBI600 (rhizobia also in formulation)
Target Pathogen/Disease: Fusarium spp., Rhizoctonia spp, Aspergillus
Crop: soybean, alfalfa, dry/snap beans, peanuts
Application method: slurry, damp and dry inoculation of seed
Manufacturer/Distributor: Becker Underwood, 801 Dayton Ave., PO BOX 667, Ames, IA 50010. Phone: 515-232-5907, FAX: 515-232-5961, www.beckerunderwood.com
     

Kodiak (several formulations)

Biocontrol Agent: Bacillus subtilis GB03
Target Pathogen/Disease: Rhizoctonia solani, Fusarium spp., Alternaria spp., and Aspergillus spp. that attack roots
Crop: cotton, legumes
Formulation: dry powder; usually applied with chemical fungicides
Application: added to a slurry mix for seed treatment; hopper box treatment
Manufacturer/Distributor: Gustafson, Inc., 1400 Preston Rd, Suite 400, Plano, TX  75093 USA. Phone 1-800-248-6907 or 1-972-985-8877;  Fax: 1-972-985-1696, www.gustafson.com

 

MeloCon WG  

Biocontrol Organism: Paecilomyces lilacinus strain 251

Target Pathogen/Disease: Plant parasitic nematodes 

Crop: many

Formulation: water dispersible granule

Application Method: spray, drench, drip irrigation

Manufacturer/Distributor: Prophyta Biologischer Pflanzenschutz GmbH, Inselstrasse 12, D-23999, Malchow/Poel, Germany. Phone: 49-38425-230. Fax: 49-38425-2323. www.prophyta.com

US Distributor: WF Stoneman Company LLC. PO Box 465, McFarland, WI 53558-0465. billstoneman@charter.net

 

Mepplus  

Biocontrol Organism: Bacillus cereus BP01

Benfits: Uniform plant height, decrease in vegetative growth, larger cotton bolls 

Crop: cotton plants

Formulation:

Application Method: aerial and ground spraying

Manufacturer/Distributor: Micro-Flo Company LLC, 530 Oak Court Drive, Memphis, TN, 38117 USA. Phone: 1-800-451-8461, Fax: 901-432-5100, www.microflocompany.com

 

 

Messenger  

Biocontrol Agent: Erwinia amylovora HrpN harpin protein. 

Target Pathogen/Disease: Many. 

Crop: field, ornamental, and vegetable crops 

Formulation: powder Application: drench or spray. 

Manufacturer/Distributor: EDEN Bioscience Corporation,3830 Monte Villa Parkway, Suite 100, Bothell, WA 98021-7266 USA. Phone: 888-879-2420 or 425-806-7300, Fax: 425-806-7400, www.edenbio.com

 

 

Mycostop

Biocontrol Agent: Streptomyces griseoviridis strain K61

Target Pathogen/Disease: Fusarium spp., Alternaria brassicola, Phomopsis spp., Botrytis spp., Pythium spp., and Phytophthora spp. that cause seed, root, and stem rot, and wilt disease

Crop: field, ornamental, and vegetable crops

Formulation: powder
Application: drench, spray or through irrigation system
Manufacturer/Distributor: Verdera Oy, PO Box 1, Riihitontuntie 14 A, FIN-02201 Espoo, Finland. www.verdera.fi/homeeng.html                            U.S. Distributor: AgBio Inc., 9915 Raleigh St., Westminster, CO 80031 USA. Phone: 877-268-2020, Fax: 303-469-9598, www.agbio-inc.com
 

Nogall

Biocontrol Agent: Agrobacterium radiobacter K1026
Target Crop/Pathogen: Agrobacterium tumefaciens
Crop: fruit and nut trees, caneberries, roses, and other ornamental nursery stock
Formulation: pure culture in pre-sterilized, neutralized, finely divided peat
Application: culture diluted in nonchlorinated water then used as for seed, root, or cutting dips or sprays
Manufacturer/Distributor: Becker Underwood Pty. Ltd., RMB 1084 Pacific Highway, Somersby, NSW 2250 Australia. Phone: 1-800-558-399, Fax: 02-4340-2243, www.beckerunderwood.com/biocare                                New BioProducts, Inc., 4272 NW Pintail Place, Corvallis, OR 97330 USA. Phone: 541-752-2045; Fax: 541-754-3968,  www.newbioproducts.com

Primastop**

Biocontrol Agent: Gliocladium catenulatum  

Target Pathogen/Disease: soilborne pathogens that cause seed, root, and stem rot, and wilt disease 

Crop: ornamental, vegetable, and tree crops 

Formulation: powder Application: drench, spray or through irrigation system Manufacturer/Distributor: Kemira Agro Oy, Porkkalankatu 3, P.O. Box 330, 00101 Helsinki, Finland; Phone 358-0-13-211; FAX 358-0 694-1375. 

U.S. Distributor: AgBio Development Inc., 9915 Raleigh St., Westminster, CO 80031; Phone 877-268-2020, 303-469-9221; FAX 303-469-9598.  www.agbio-inc.com

 
Serenade / Rhapsody/ Serenade Garden
Biocontrol Agent: Bacillus subtilis QWT713
Target Crop/Pathogen: powdery mildew, downy mildew, Cercospora leaf spot, early blight, late blight, brown rot, fire blight, and others
Crop: cucurbits, grapes, hops, vegetables, peanuts, pome fruits, stone fruits, and others
Formulation: wettable powder
Application: spray
Manufacturer/Distributor: AgraQuest, Inc., 1530 Drew Avenue, Davis, CA 95616 USA. Phone: 1-530-750-0150, Fax: 1-530-750-0153, www.agraquest.com
 
Sonata
Biocontrol Agent: Bacillus pumilus
Target Crop/Pathogen: powdery mildew, downy mildew, Cercospora leaf spot, early blight, late blight, brown rot, fire blight, and others
Crop: cucurbits, grapes, hops, vegetables, peanuts, pome fruits, stone fruits, and others
Formulation: wettable powder
Application: spray
Manufacturer/Distributor: AgraQuest, Inc., 1530 Drew Avenue, Davis, CA 95616 USA. Phone: 1-530-750-0150, Fax: 1-530-750-0153, www.agraquest.com
 

SoilGard

Biocontrol Agent: Gliocladium virens GL-21
Target Crop/Pathogen: damping-off and root rot pathogens especially Rhizoctonia solani and Pythium spp.
Crop: ornamental and food crop plants grown in greenhouses, nurseries, homes, and interiorscapes
Formulation: granules
Application: granules are incorporated in soil or soilless growing media prior to seeding
Manufacturer/Distributor: Certis USA LLC, 9145 Guilford Road, Suite 175, Columbia, MD 21046 USA. Phone: 1-301-604-7340 or 1-800-847-5620, Fax: 1 301-604-7015, www.certisusa.com
 

Spot-Less Biofungicide

Biocontrol Organism: Pseudomonas aureofaciens Tx-1
Target Pathogen/Disease: dollar spot, anthracnose, pythium, pink snow mold
Crop: turfgrass
Formulation:
Application Method: added directly to sprinkler system
Manufacturer/Distributor: Turf Science Laboratories, Inc., 2121 Hoover Ave., National City, CA 91950 USA.

 

Subtilex

Biocontrol Agent: Bacillus subtilis MBI600

Target Pathogen/Disease: Fusarium spp., Rhizoctonia spp., and Pythium spp. that cause seed and root rots

Crop: field, ornamental, and vegetable crops

Formulation: powder

Application: drench, spray or through irrigation system

Manufacturer/Distributor: Becker Underwood, 801 Dayton Ave., PO BOX 667, Ames, IA 50010. Phone: 515-232-5907, FAX: 515-232-5961, www.beckerunderwood.com

 
T-22, RootShield , PlantShield
Biocontrol Agent: Trichoderma harzianum Rifai strain KRL-AG2 (T-22)
Target Pathogen/Disease: Pythium spp., Rhizoctonia solani, Fusarium spp.
Crop: trees, shrubs, transplants, all ornamentals, cabbage, tomato, cucumbe
Formulation: granules or wettable powder
Application: granules mixed with soil or potting medium; powder mixed with water and added as a soil drench
Manufacturer/Distributor: Bioworks, Inc., 345 Woodcliff Dr., First Floor, Fairport, NY 14450 USA. Phone: 1-800-877-9443 or 585-641-0581, Fax: 1-800-903-2377 or 585-641-0584, www.bioworksbiocontrol.com

 

Taegro, Tae-Technical
Biocontrol Agent: Bacillus subtilis var. amyloliquefaciens FZB24
Target Pathogen/Disease: Rhizoctonia and Fusarium
Crop: Only in greenhouses and other indoor sites on shade and forest tree seedlings, ornamentals, and shrubs.  Not permitted for use on food crops.
Formulation: granules
Application: suspend in water and either drench or dip plants
Manufacturer/Distributor: Earth Biosciences Inc., 106 Somerset Ave., Fairfield, CT 06824, USA.

 

YiedShield

Biocontrol Agent: Bacullus pumillus GB34.

Target Pathogen/Disease: Soilborne fungal pathogens causing root diseases. 

Crop: soybean. 

Formulation: dry powder.

Application: added to a slurry mix for seed treatment; hopper box treatment. Manufacturer/Distributor: Gustafson, Inc., 1400 Preston Rd, Plano TX  75093 USA; Phone 1-800-248-6907 or 1-972-985-8877; FAX 1-972-985-1696.  www.gustafson.com

 

*EPA Registration pending.

**Source not independently confirmed.


Copyright © 2002 APS Biological Control Committee.  All rights reserved.

Revised: October 27, 2005