Dr. Qiuhong Wang,  Assistant Professor, Research Scientist

Bachelor of Medicine (M.D. equivalent) majoring in Preventive Medicine (Beijing Medical University, China)1994

Research staff member in the Institute of Virology in China, developed a sensitive assay for the detection of hepatitis A virus from shellfish, which greatly enhanced the prevention of hepatitis A virus transmission through contaminated shellfish.

Master's student majoring in Molecular Virology at the University of Tokyo, performed the first comprehensive genetic analysis of human and animal astroviruses. This work provided detailed sequence analysis of the complete structural protein of astroviruses, critical for comparative virology and diagnostic assays.

Ph.D study at Dr. Linda Saif's lab at the Food Animal Health Research Program at the OARDC, The Ohio State University, I discovered new noroviruses and sapoviruses from domestic pigs and demonstrated that porcine noroviruses and sapoviruses are closely related to human noroviruses and sapoviruses, respectively.

Developed sensitive methods for the detection of these newly identified porcine caliciviruses and performed the first prevalence study of these viruses showing that some porcine norovirus and sapovirus strains were widely distributed in pig populations. These results are very important to public health because they suggest that emerging human caliciviruses associated with new epidemic strains of unknown origin may evolve from animal sources and that scientists need to survey animal reservoirs to predict or prevent human calicivirus infections. Based on our data, we were first to propose that human norovirus infections may be zoonotic. Subsequently, more evidence to support this hypothesis has been reported worldwide.

Post-doctoral training at the Medical College of Wisconsin, worked on the immune evasion mechanisms of herpesvirus 7.

Research Scientist at FAHRP, OARDC, The Ohio State University working with Dr. Linda Saif, a member of the National Academy of Sciences and a leading virologist and mucosal immunologist working on caliciviruses, human rotavirus vaccines and SARS-related coronaviruses.

Research on RNA viruses such as caliciviruses that infect both animals and humans. Because RNA viruses evolve quickly and change disease patterns and host tropisms, they are the leading cause of emerging disease in humans.

Current research focus is on enteric caliciviruses.

Qiuhong Wang, Ph.D.
Adjunct Assistant Professor & Research Scientist
Food Animal Health Research Program
OARDC/The Ohio State University
Wooster, Ohio 44691
wang.655@osu.edu
(330)263-3740 (office)
FAX (330)263-3677

Journal Articles:

Stanislav V. Sosnovtsev, Karin Bok, Qiuhong Wang, Linda J. Saif, Kim Y. Green. 2013. Complete Genome Sequence of GII.4 Human Norovirus HS191. Genome Announcement [Epub ahead of print].

Zufan Sisay, Qiuhong Wang*, Tomoichiro Oka and Linda Saif*. Prevalence and molecular characterization of porcine enteric caliciviruses and first detection of porcine kobuviruses in US Swine. Arch Virol [Epub ahead of print]. (*corresponding authors).

Seiya Harada, Tomoichiro Oka, Eisuke Tokuoka , Naoko Kiyota , Koichi Nishimura , Yasushi Shimada, Takehiko Ueno, Shigeru Ikezawa , Takaji Wakita , Qiuhong Wang , Linda J. Saif and Kazuhiko Katayama. 2012. A confirmation of sapovirus re-infection gastroenteritis cases with different genogroups and genetic shifts in the evolving sapovirus genotypes, 2002-2011. Arch Virol 157:1999-2003.

Kwonil Jung, Qiuhong Wang, Yunjeong Kim, Kelly Scheuer, Zhenwen Zhang, Quan Shen, Kyeong-Ok Chang, Linda J. Saif. 2012. The effects of simvastatin or interferon-α on infectivity of human norovirus using a gnotobiotic pig model for the study of antivirals. PLoS One 7: e41619. doi:10.1371/journal.pone.0041619.

Esseili M., Q.Wang*, Z. Zhang and L.J. Saif* 2012. Internalization of Sapovirus, a surrogate for Norovirus, in romaine lettuce and the effect of lettuce latex on virus infectivity. Appl Environ Microbiol. 78:6271-9. (*corresponding authors).
Wang Q., Z. Zhang and L.J. Saif. 2012. Stability of and attachment to lettuce by a culturable porcine sapovirus surrogate for human caliciviruses. Appl Environ Microbiol. 78:3932-40.

Pinto P, Q. Wang, N. Chen, E.J. Dubovi, J.B. Daniels, L.M. Millard, C. Buonavoglia, V. Martella, L.J. Saif. 2012. Discovery and genomic characterization of noroviruses from a gastroenteritis outbreak in domestic cats in the US. PLoS One 7:e32739.

Esseili M., Q.Wang*, L.J. Saif* 2012. Binding of Human GII.4 Norovirus Virus-Like Particles to Carbohydrates of Romaine Lettuce Leaf Cell Wall Materials. Appl Environ Microbiol 78:786-794. (*corresponding authors).

Takanashi S., Q. Wang*, N. Chen, Q. Shen, K. Jung, Z. Zhang, M. Yokoyama, L. Lindesmith, R.S. Baric, L.J. Saif*. 2011. Characterization of the emerging GII.g/GII.12 norovirus from a gastroenteritis outbreak in US in 2010. J Clin Microbiol. 49:3234-3244. (*corresponding authors)

Wang Q., K. Scheuer, Z. Zhang, W. A. Gebreyes, B. Z. Molla, A. E. Hoet and L.J. Saif. 2011. Characterization and Prevalence of a New Porcine Calicivirus in Swine, United States. Emerg Infect Dis 17: 1103-1106.

Glosson, N. L., P. Gonyo, N. A. May, C. L. Schneider, L. C. Ristow, Q. Wang, and A. W. Hudson. 2010. Insight into the mechanism of human herpesvirus 7 U21-mediated diversion of class I MHC molecules to lysosomes. J Biol Chem 285:37016-29.

Wang, Q. H., V. Costantini, and L. J. Saif. 2007. Porcine and Human Enteric Caliciviruses: Comparative Diagnosis, Epidemiology and Genetic and Antigenic Relatedness. Vaccine 25: 5453-5466. Review.

Cheetham S, M. Souza, R. McGregor, T. Meulia, Q. Wang, L. J. Saif. 2007. Binding patterns of human norovirus-like particles to buccal and intestinal tissues of gnotobiotic pigs in relation to A/H histo-blood group antigen expression. J Virol 81:3535-44.

Wang, Q. H., M. Souza, J. A. Funk, W. Zhang, and L. J. Saif. 2006. Prevalence of noroviruses and sapoviruses in swine of various ages determined by reverse transcription-PCR and microwell hybridization assays. J Clin Microbiol 44 2057-2062.

Wang, Q. H., K. O. Chang, M. K. Han, S. Sreevatsan, and L. J. Saif. 2006. Development of a new microwell hybridization assay and an internal control RNA for the detection of porcine noroviruses and sapoviruses by reverse transcription-PCR. J Virol Methods. 132: 135-145.

Wang, Q. H., M. K. Han, J. A. Funk, G. Bowman, and L. J. Saif. 2005. Genetic diversity and recombination of porcine sapoviruses. J Clin Microbiol. 43:5963-5972.

Wang, Q. H., M. G. Han, S. Cheetham, M. Souza, J. A. Funk, and L. J. Saif. 2005. Porcine noroviruses related to human noroviruses. Emerg Infect Dis. 11: 1874-1881.

Han, M. G., Q. Wang, J. R. Smiley, K. O. Chang, and L. J. Saif. 2005. Self-assembly of the recombinant capsid protein of a bovine norovirus (BoNV) into virus-like particles and evaluation of cross-reactivity of BoNV with human noroviruses. J Clin Microbiol 43:778-85.

Chang, K. O., S. S. Sosnovtsev, G. Belliot, Q. Wang, L. J. Saif, and K. Y. Green. 2005. Reverse genetics system for porcine enteric calicivirus, a prototype sapovirus in the Caliciviridae. J Virol 79:1409-16.

Tang, Y., Q. Wang, and Y. M. Saif. 2005. Development of a ssRNA internal control template reagent for a multiplex RT-PCR to detect turkey astroviruses. J Virol Methods 126:81-6.

Wang, Q. H., J. Kakizawa, L. Y. Wen, M. Shimizu, O. Nishio, Z. Y. Fang, and H. Ushijima. 2001. Genetic analysis of the capsid region of astroviruses. J Med Virol 64:245-55.

Sakamoto, T., H. Negishi, Q. H. Wang, S. Akihara, B. Kim, S. Nishimura, K. Kaneshi, S. Nakaya, Y. Ueda, K. Sugita, T. Motohiro, T. Nishimura, and H. Ushijima. 2000. Molecular epidemiology of astroviruses in Japan from 1995 to 1998 by reverse transcription-polymerase chain reaction with serotype-specific primers (1 to 8). J Med Virol 61:326-31.

Zhao, W., T. Wu, J. Li, Z.Y. Fang, Q. Wang, and J. Zhang. 1997. Study on the genes of poliovirus type I isolated from environmental water by PCR. Chinese Journal of virology 13(1) (Chinese).

Wang, Q. H., and Z. Y. Fang. 1996. Molecular biology of Norwalk-like viruses. Foreign Medical Sciences (field: Virology) 3:27-31 (Chinese). Review.

Wang, Q. H., Z. Y. Fang, Z. Lu, D. Zhou, J. Zhang, and D. Wu. 1996. Detection of hepatitis A virus contamination in shellfish by antibody capture/polymerase chain reaction. Chinese Journal of virology 12:123-128 (Chinese).

Pan, N., Z. Y. Fang, J. Yan, Q. H., Wang, Z. Gong, and J. Zhang. 1995. Molecular epidemiology of group A rotaviruses during 1989-1992 in Hubei province of China. Chinese Journal of Experimental and Clinical Virology 9:250-253 (Chinese).

Wang, Q. H., and Y. Chang. 1995. The effects of chemical toxins on secretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH) of male pituitary (review). Foreign Medical Sciences (field: Hygiene) 3:140-144 (Chinese). Review.

Wang, Q. H., and Y. Chang. 1995. The effects of chemical toxins on secretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH) of male pituitary (review). Foreign Medical Sciences (field: Hygiene) 3:140-144 (Chinese). Review.

1. Chang, Y., S. Lu, X. Jin, Q. H., Wang, and Z. Liu. 1994. Effects of HgCl2 on Sertoli cells of testis in rats. Journal of Health Toxicology 8:300 (Chinese).

Book Chapters:

Leon, J. S., M. Souza, Q. Wang, E. R. Smith, L. J. Saif, and C. L. Moe. 2008. Immunology of Norovirus Infection. In M. Vajdy (ed.), Immunity against Mucosal Pathogens. Springer, New York.