Dr Renukaradhya Gourapura

Assistant Professor

Education

    * Postdoctoral Fellow, 2002-2008, Indiana University School of Medicine, Indianapolis, Indiana
    * Ph.D., 2002, Indian Institute of Science, Bangalore, India
    * MVSc, 1994, Veterinary College, Univ. Agri. Sci. Bangalore, India
    * DVM, 1991, Veterinary College, Univ. Agri. Sci. Bangalore, India


Research

Mucosal immunology is increasingly gaining attention as an area of great potential for the development of vaccines and immunotherapy. We are interested in understanding mucosal immune responses in the respiratory and gastrointestinal tract of pigs and other species of food animals following microbial infections. Our main goal is to understand host-pathogen interactions, pathogenesis, microbial immune evasion mechanisms and development of novel mucosal vaccines against infectious diseases. Emphasis is on understanding the role of mucosal innate immune responses mediated through natural killer (NK) cells, T cells, NKT cells, dendritic cells and macrophages. Currently, we are involved in elucidation of mucosal immune responses to porcine reproductive and respiratory syndrome (PRRS) virus in the respiratory tract of pigs and development of effective mucosal vaccine to PRRS. Identify potential mucosal candidate adjuvants capable of activating primarily mucosal innate immune cells in the respiratory tract of pigs which in turn activates the adaptive arm of the immune system, and use selected potential adjuvant/s along with specific vaccine antigens to protect against infections/zoonotic diseases of food animals.

Recent Publications

Khan, M.A, R.M. Gallo, G.J. Renukaradhya, W. Du, J. Gervay-Hague, and R.R. Brutkiewicz (2009). Statins Impair CD1d-mediated antigen presentation through inhibition of prenylation. J. Immunol. (In press).

Li, W., M.H. Sofi, D.G. Wei, W. Du, J. Gervay-Hague, G.J. Renukaradhya, R.R. Brutkiewicz, C.H. Chang (2009). MHC class II-expressing thymocytes suppress invariant NKT cell development. Immunol. Cell Biol. 87(2):186-189.

Renukaradhya, G.J., M.A. Khan, D.Shaji,and R.R. Brutkiewicz (2008). The VSV Matrix Protein Inhibits CD1d-mediated Antigen Presentation through Activation of the p38 MAPK Pathway. J.Virol. 82(24):12535-12542.

M.A. Khan, V. Sriram, G. J. Renukaradhya, M. Nagala, W. Du, J. Gervay-Hague and R.R. Brutkiewicz (2008).  Apoptosis-induced inhibition of CD1d-mediated antigen presentation:  Different roles for caspases and p38 MAPK.  Immunol. 125(1):80-90.

Renukaradhya, G.J., M.A. Khan, M. Vieira, W. Du, J. Gervay-Haque, and R.R. Brutkiewicz (2008).  Type I NKT cells protect (and Type II NKT cells suppress) the host's innate antitumor immune response to a B-cell lymphoma.  Blood, 111(12):5637-5645.

Brutkiewicz, R.R., C.A. Willard, K.K. Gillett-Heacock, M.R. Pawlak, J.C. Bailey,    M.A. Khan, M. Nagala, W. Du, J. Gervay-Hague and G. J. Renukaradhya (2007). Protein kinase C d is a critical regulator of CD1d-mediated antigen presentation.  Euro. J. Immunol. 37(9):2390-2395.

Yao, Y., P. Li, P. Singh, A.T. Thiele, D.S. Wilkes, G.J. Renukaradhya, R.R. Brutkiewicz, J.B. Travers, G.D. Luker, S.C.  Hong, J.S. Blum, C.H. Chang (2007).  Vaccinia virus infection induces dendritic cell maturation but inhibits antigen presentation by MHC class II.  Cell. Immunol, 246(2):92-102.

Broxmeyer, H.E., A. Dent, S. Cooper, G. Hangoc, Z.Y.  Wang, W. Du, J. Gervay-Haque, V. Sriram, G.J. Renukaradhya and R.R. Brutkiewicz (2007).  A role for Natural Killer T cells and CD1d in counteracting suppression of hematopoiesis in mice Induced by infection with murine cytomegalovirus. Exp. Hematol. 35(4/1):87-93.

Larkin, J., G.J. Renukaradhya, V. Sriram, W. Du, J. Gervay-Hague, and R.R. Brutkiewicz (2006).  CD44 differentially activates mouse NK T cells and conventional T cells.  J.  Immunol. 177(1):268-279.

Renukaradhya, G.J., V. Sriram, W. Du, J. Gervay-Hague, L.V. Kaer, and R.R. Brutkiewicz (2006).  Inhibition of antitumor immunity by invariant natural killer T cells in a T cell lymphoma model in vivo. Int. J. Cancer 118(12):3045-3053.

Renukaradhya, G.J., T.J.R. Webb, M.A. Khan, Y.L. Lin, W. Du, J. Gervay-Hague, and R.R. Brutkiewicz (2005).  Virus-induced inhibition of CD1d1-mediated antigen presentation:  reciprocal regulation by p38 and ERK.  J. Immunol.  175(7):4301-4308.

Renukaradhya, G.J., V. Sriram, K. Polakova, G. Russ, and R.R. Brutkiewicz (2004). Development of a quantitative cell-based intracellular ELISA for the screening of B cell hybridoma supernatants: a novel rapid assay to detect positive clones. Hybridoma and Hybridomics  23:373-379.

Khandelwal, A., G.J. Renukaradhya, M. Rajasekhar, G. Lakshmisita and M.S. Shaila (2004). Systemic and oral immunogenicity of hemagglutinin protein of rinderpest virus expressed by transgenic peanut plants in a mouse model. Virology  323(2):284-91.

Renukaradhya, G.J., K.B. Suresh, M. Rajasekhar and M.S. Shaila (2003). Development of recombinant hemagglutinin competitive ELISA kit for rinderpest sero-surveillance. J Clin. Microbiol. 41(3):943-947.

Renukaradhya, G.J., G. Sinnathamby, S. Seth, M. Rajasekhar and M.S. Shaila (2002).  Mapping of B-cell epitopic sites and delineation of functional domains on the Hemagglutinin-Neuraminidase Protein of Peste des petits ruminants virus. Virus Res. 90(1-2):171-185.

Renukaradhya, G.J., S. Isloor and M. Rajasekhar (2002). Epidemiology, zoonotic aspects, vaccination and control / eradication of brucellosis in India. Vet. Microbiol. 90:183-195.

Renukaradhya, G.J., S. Mitra-Kaushik, G. Sinnathamby, M. Rajasekhar and M.S. Shaila (2002). Mapping of B-cell Epitopes of Hemagglutinin Protein of Rinderpest Virus.  Virology 298(2): 214-223.

Sinnathamby, G., G.J. Renukaradhya, M.Rajasekhar, R. Nayak and M.S. Shaila (2001). Recombinant hemagglutinin protein of rinderpest virus expressed in insect cells induces cytotoxic T-cell responses in cattle.  Viral Immunol. 14(4):349-358.

Renukaradhya, G.J., S. Isloor, J. Crowther, M. Robinson and M. Rajasekhar (2001).  Development and field validation of Avidin-biotin ELISA kit for bovine brucellosis. Rev.sci.tech.Off.int.Epiz. 20(3):749-756.