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Immune response to rotavirus DNA vaccines

NIAID, NIH Grant (Ended 2005)

(Co-PIs: L. Saif, J. Hermann)

 

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Objectives

The goal of these studies was to develop rotavirus DNA vaccines that will provide the basis for prevention of rotavirus infections in humans by DNA vaccination. Gnotobiotic pigs, the only animal models that can be clinically infected with human rotaviruses to mimic human disease were used to analyze primary immune responses to rotavirus DNA vaccines, and to test homotypic (vaccine serotype) and heterotypic (unrelated serotype) immunity to human rotavirus.

 

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